since Update 5.0.61428 Key Sequences are not working anymore on Web Page Connections (Chrome)
I think the web page does not get the focus since the key sequence will run outside of the web page and is changing stuff in the royal ts interface
as mentioned here, I'm not able to repro the issue anymore. I've also published a new beta release just now here: https://www.royalapps.com/go/kb-ts-win-downloadbeta
It ships with the most recent Chromium engine. Can you check if you are able to repro the issue with this version?